Travel At High Altitude, a booklet that can be freely download by clicking this link - a guide to staying healthy in the mountains.

1. Booking Information for Medex Hidden Valley Expedition 2008

2. Download latest Newsletter

3. The International HAPE Database www.altitude.org/hape.htm

4. Important dates for 2008

5. Research proposals for Hidden Valley Expedition 2008

Bibliography of Medical Expeditions Publications from

"The British Mount Everest Expedition 1994" and

"Kangchenjunga 1998"

Cough, nasal moistening and airways responsiveness

Original Articles

Barry P.W., N.P. Mason and C. O'Callaghan. Nasal muco-ciliary transport is  impaired at altitude. Eur. Resp. J. 10:35-7, 1997.

Barry P.W., N.P. Mason, M. Riordan and C. O'Callaghan. Cough frequency and  cough receptor sensitivity are increased in man at altitude. Clin. Sci. 93:181-6, 1997.

Pollard A.J., N.P. Mason, P.W. Barry, R.C. Pollard, D.J. Collier, R.S. Fraser,  M.R. Miller, J.S. Milledge. Effect of altitude on spirometric parameters and  the performance of peak flow meters. Thorax. 51:175-8, 1996.

Pollard A.J., N.P. Mason, P.W. Barry, D.J. Collier, R.C. Pollard, R.S. Fraser, M.R. Miller and J.S. Milledge. Hypoxia, hypocapnia and spirometry at altitude. Clin. Sci. 92:593-8, 1997.

Letters

Barry P.W., N.P. Mason and D.J. Collier. Everest study supports use of capillary sampling. B.M.J.  310:1072, 1995

Pollard R.C. and Pollard A.J. Asthma in cross-country skiers. B.M.J.6923 (308): 274, 1994.*

Abstracts

Bakewell, S. E., N.D. Hart, C.M. Wilson, R. McMorrow, D. Collier, and P.B. Barry.  A randomised, double blind, placebo controlled trail of the effect of inhaled nedocromil sodium or salmeterol xinafoate on the citric acid cough threshold in subjects travelling to high altitude. In: Hypoxia: Into the Next Millennium, edited by R. C. Roach, P. D. Wagner and P. H. Hackett. New York: Plenum/Kluwer Academic Publishing. P.362, 1999.

Bakewell S.E., C.M. Wilson, M.R. Miller, N.D. Hart, R.C.N. Mcmorrow, P.W. Barry, D.J. Collier, S.J. Watt, A.J. Pollard. Increased resting bronchial tone in normal subjects acclimatised to hypobaric hypoxia.  High Altitude Medicine and Biology 1 (3): p 273, 2000

Barry P.W., N.P. Mason, C. O’Callaghan. Muco-ciliary clearance at humans at altitude. J. Physiol.  487: 106P, 1995

Barry P.W., N.P. Mason, M. Riordan and C. O’Callaghan. Changes in cough sensitivity at altitude Thorax. 50 (2): A33, 1995.

Barry P.W., N.P. Mason, A. Nickol, A. Datta, J.S. Milledge, C.B. Wolff and D.J. Collier. Cough Receptor sensitivity and dynamic ventilatory response to carbon dioxide in man acclimatised to high altitude. J. Physiol. 497; 29P-30P, 1996.

Barry P.W., N.P. Mason, A. Nickol A, A. Datta, J.S. Milledge, C.B. Wolff and D.J. Collier. Cough Receptor sensitivity and dynamic ventilatory response to carbon dioxide in man acclimatised to high altitude. In Hypoxia - Women at altitude eds. Houston CS, Coates G. CS Houston, Burlington, USA. p303, 1997.

Barry, P. W., N.P. Mason, and J.P. Richalet. Nasal peak inspiratory flow during a simulated ascent to extreme altitude - Operation Everest III. In: Hypoxia: Into the Next Millennium, edited by R. C. Roach, P. D. Wagner and P. H. Hackett. New York: Plenum/Kluwer Academic Publishing. p. 363, 1999.

Barry P.W., N.P. Mason, C. Callaghan. Inspiratory flow at altitude. In Hypoxia -Women at altitude eds. Houston CS, Coates G. CS Houston, Burlington, USA CHECK THIS REF

Hart, N. D., C.M. Wilson, R. McMorrow, D.J. Collier, D. Williams, M.R. Miller and A.J. Pollard. Changes in airway responsiveness induced by chronic exposure to hypoxia.  In: Hypoxia: Into the Next Millennium, edited by R. C. Roach, P. D. Wagner and P. H. Hackett. New York: Plenum/Kluwer Academic Publishing. p. 386, 1999.

Mason N.P., A.J. Pollard, P.W. Barry, R.C. Pollard, D.J. Collier and J.S. Milledge. Spirometry and chronic hypoxia. In Hypoxia and the brain eds. Sutton JR, Houston CS, Coates G. CS Houston, Burlington, USA. p330, 1995.

Mason N.P., A.J. Pollard, P.W. Barry, R.C. Pollard, D.J. Collier, R.S. Fraser, M.R. Miller and J.S. Milledge. Changes in spirometry at altitude. Thorax 50 (2): A67, 1995.

Mason, N. P., P. Barry, A.J. Pollard D.J. Collier, N. Taub, M.R. Miller and J.S. Milledge. Serial changes in spirometry during an ascent to 5300m.  In: Hypoxia: Into the Next Millennium, edited by R. C. Roach, P. D. Wagner and P. H. Hackett. New York: Plenum/Kluwer Academic Publishing. p. 411, 1999.

Pollard A.J., N.P. Mason, P.W. Barry, R.C. Pollard, R.S. Fraser, D.J. Collier and J.S. Milledge. Changes in spirometry at altitude. In Hypoxia and the Brain eds. Sutton JR, Houston CS, Coates G. CS Houston, Burlington, USA. p. 334, 1995.

Pollard A.J., P.W. Barry, N.P. Mason, D.J. Collier, R.C. Pollard, P.F.A. Pollard, R.S. Fraser, M.R. Miller and J.S. Milledge.  Hypoxia, hypocapnia and spirometry at altitude. Thorax 50 (2): A61, 1995.

Wilson, C. M., S.E. Bakewell, R.C.N. McMorrow, N.D. Hart, D.J. Collier, D. Williams, and P.W. Barry. Impairment of nasal mucociliary clearance at altitude may be reduced by intermittent moistening of the nasal passages. In: Hypoxia: Into the Next Millennium, edited by R. C. Roach, P. D. Wagner and P. H. Hackett. New York: Plenum/Kluwer Academic Publishing. p. 440, 1999.

Control of breathing

Abstracts

Collier D.J., A. Nickol, J.S. Milledge, A. Datta, C.J. Collier and C.B. Wolff. Dynamic chemosensitivity to carbon dioxide increases with acclimatisation to chronic hypoxia in man. In Hypoxia and the Brain eds. Sutton JR, Houston CS, Coates G. CS Houston, Burlington, USA.:p.330, 1995

Collier D.J, A. Nickol, P. Pollard, J.S. Milledge and C.B. Wolff. Ventilatory dynamics alter with acclimatisation. In Hypoxia and the Brain eds. Sutton JR, Houston CS, Coates G. CS Houston, Burlington, USA. p330, 1995.

Collier D.J., A. Nickol, P. Pollard, J.S. Milledge and C.B. Wolff. Ventilatory dynamics alter with acclimatisation to chronic hypoxia in man. J. Physiol.  487:108P-109P, 1995.

Collier D.J., A. Nickol, J.S. Milledge, A. Datta, C.J. Collier and C.B. Wolff. Dynamic chemosensitivity to carbon dioxide increases with acclimatisation to chronic hypoxia in man. J. Physiol. 487:109P-110P, 1995.

Collier D.J., J.S. Milledge, A.H. Nickol, H. van Ruiten and C.B. Wolff C.B.  Human dynamic ventilatory responsiveness to carbon dioxide exists in normoxia, but not in acute hypoxia. J. Physiol. 515P:  76, 1998.

Nickol, A. H., D.J. Collier, J.S. Milledge, H. van Ruiten and C.B. Wolff.  The ventilatory response to timed inspiratory pulses of CO₂ during acclimatisation to hypoxia. In: Hypoxia: Into the Next Millennium, edited by R. C. Roach, P. D. Wagner and P. H. Hackett. New York: Plenum/Kluwer Academic Publishing, p. 417, 1999

Nickol A.H., H. van Ruiten, E. Swenson, C.B. Wolff, J.S. Milledge and D.J. Collier.  Abolition of the Ventilatory Response to Timed Inspiratory CO₂ Pulses in Man using the Carbonic Anhydrase Inhibitor, Acetazolamide. High Altitude Medicine and Biology. 1 (3): 255, 2000

Nickol A.H., H. van Ruiten, E. Swenson, C.B. Wolff, J.S. Milledge and D.J. Collier. Abolition of the Ventilatory Response to Timed Inspiratory CO₂ Pulses in Man using the Carbonic Anhydrase Inhibitor, Acetazolamide. Accepted for presentation at the ATS Meeting (March 2001)

Nickol A.H., C. Collier, C.B. Wolff, J.S. Milledge and D.J. Collier. Abolition of the Ventilatory Response to Timed Inspiratory CO₂  Pulses in Man Acclimatised to High Altitude During Artificial Descent Using Supplementary Oxygen. Accepted for presentation at the ATS Meeting (March 2001)

Respiratory Muscle Function and Training During Ascent to High Altitude.

Abstract

Romer L. and A. McConnell. Spontaneous changes in respiratory muscle function during ascent to high altitude. J. Physiol. 523: P216-7, 1999.

Nickol A.H., L.M. Romer, A.K. McConnell and D.A. Jones.  The Effects of Specific Inspiratory Muscle Training upon Respiratory Muscle Function and Dyspnoea at High Altitude. Accepted for presentation at "Hypoxia 2001"

Evaluation of a Closed Circuit Breathing System

Abstract

Steiner, U., R. Fischer, K. Voll, and R. M. Huber. Evaluation of a closed circuit breathing system for treatment of high altitude related disease. In: Hypoxia: Into the Next Millennium, edited by R. C. Roach, P. D. Wagner and P. H. Hackett. New York: Plenum/Kluwer Academic Publishing, p. 431, 1999.

Blood Pressure and Pulmonary Arterial Pressure

Abstracts

Collier D.J., N.P. Mason, A.J. Pollard, T. Mercer and J.S. Milledge. Systemic blood pressure increases during trekking ascent to high altitude in man. In Hypoxia - Women at altitude eds. Houston CS, Coates G. CS Houston, Burlington, USA p308, 1997.

Dubowitz, G., and Peacock A.J. Pulmonary artery pressure variation measured by Doppler echocardiography in healthy subjects at 4250m. In: Hypoxia: Into the Next Millennium, edited by R. C. Roach, P. D. Wagner and P. H. Hackett. New York: Plenum/Kluwer Academic Publishing. p. 378, 1999.*

Cold Induced Vasodilatation

Original Article

Daanen H.A. and H.J.A. van Ruiten.  Cold-induced peripheral vasodilation at high altitudes - a field study. High Altitude Medicine and Biology 1 (4):  323 - 329, 2001

Abstract

van Ruiten, H. J. A. and H.A.M. Daanen. Cold induced vasodilation at altitude.  In: Hypoxia: Into the Next Millennium, edited by R. C. Roach, P. D. Wagner and P. H. Hackett. New York: Plenum/Kluwer Academic Publishin. , p. 436, 1999.

Visual Function

Abstracts

Depla D.N., A.M. Fry and F.W. Fitzke. Assessment of visual function at altitude using movement detection perimetry. In Hypoxia and the Brain eds. Sutton JR, Houston CS, Coates G. CS Houston, Burlington, USA. p319, 1995.

Howarth M.W. and D.N. Depla. The effect of hypoxia at high altitude on pupil response to light.  High Altitude Medicine and Biology  1 (3): 241, 2000

Balance and Postural Sway

Abstracts

Collier DJ, Collier CJ, France J, Rosenberg ME. Visual stabilisation of postural sway deteriorates at high altitude in man. Journal of Physiology 1996; 497: 62P.

Collier DJ, Collier CJ, Rosenberg ME. Postural sway deficit at high altitude. In Hypoxia - Women at altitude eds. Houston CS, Coates G. CS Houston, Burlington, USA. p308, 1997.

Rosenberg M.E., J.S. Milledge, G. Rivett and D.J. Collier. Effect of altitude on the perception of vertical and horizontal and on sway. J. Physiol. 518.P, 1999.

Motor Function

Silber E. Upper limb motor function at 5000 metres: determinants of performance and residual sequelae.  J Neurol Neurosurg Psychiatry. 69: 233 - 236, 2000

Cerebral Blood Flow

Wolff C.B. Cerebral blood flow and oxygen delivery at high altitude. In press: High Altitude Medicine and Biology, 1: (1) 2000.*

Acupuncture

Richards, P. The use of acupuncture in the prophylaxis and treatment of altitude induced headache and nausea. In: Hypoxia: Into the Next Millennium, edited by R. C. Roach, P. D. Wagner and P. H. Hackett. New York: Plenum/Kluwer Academic Publishing, p. 424, 1999.

  Acute Mountain Sickness and Carbonic Anhydrase Inhibition

Abstracts

Collier D.J., J. Nathan, R.J. Flower, C.B. Wolff, J.S. Milledge and E.R. Swenson. Renal selective carbonic anhydrase inhibition prevents acute mountain sickness in man. J.Physiol. 497: 30P-31P, 1996.

Collier D.J., C.B. Wolff, J. Nathan, E.R. Swenson, J.S. Milledge. Benzolamide, acidosis and acute mountain sickness. In Hypoxia - Women at altitude eds. Houston CS, Coates G. CS Houston, Burlington, USA p307, 1997.

Milledge J.S., J. Nathan, C.B. Wolff, E.R. Swenson, D.J. Collier. Selective carbonic anhydrase inhibition prevents acute mountain sickness in man. Acta Andina. 5:32, 1996.

Richards P., A.H. Nickol, A.J. Pollard and D.J. Collier. Arterial Oxygen Saturation as a Predictor of Acute Mountain Sickness During Gradual Ascent to 5100m.  Accepted for presentation at "Hypoxia 2001".

  Letter

Pollard A.J. Treatment of Acute Mountain Sickness. B.M.J.  311:629, 1995*

Pollard A.J. and R.C. Pollard. Decompression sickness on mountains. J. of the Royal College of Physicians of London. 28(1): 88-89, 1994.*

  Original article

Dubowitz G. Effect of temazepam on oxygen saturation and sleep at high altitude: randomised placebo controlled crossover trial.  B.M.J. 316:587:9, 1998.

  Abstracts

Dubowitz G. Effect of Temazepam on sleep at high altitude. In Hypoxia and the Brain eds. Sutton JR, Coates G. CS Houston, Burlington, USA. 1995

Dubowitz G. Oxygen saturation during sleep and the effect of the benzodiazepine Temazepam. J. Wilderness and Env. Med. 6:432, 1995.

  Gender Differences and Women at High Altitude

Abstracts

Barry P.W., N.P. Mason and D.J. Collier. Sex differences in blood gases at altitude. In Hypoxia and the Brain eds. Sutton JR, Houston CS, Coates G. CS Houston, Burlington, USA. p330, 1995.

Collier D.J., C.J. Collier, G. Dubowitz and M.E. Rosenberg. Gender and weight loss at high altitude. In Hypoxia - Women at altitude eds. Houston CS, Coates G. CS Houston, Burlington, USA. p308, 1997.

Miller, D. Menstrual cycle abnormalities and the oral contraceptive pill at high altitude. In: Hypoxia: Into the Next Millennium, edited by R. C. Roach, P. D. Wagner and P. H. Hackett. New York: Plenum/Kluwer Academic Publishing. p. 412, 1999.

Free Radicals and Amino-Acid Metabolism

Original Articles

Bailey, D.M. Acute mountain sickness - the "poison of the pass" Brit. J. Sports Med. 33: 376, 1999. (Editorial)

Bailey D.M, B. Davies J.S. Milledge, M. Richards, S.R.P. Williams, M. Jordinson and J. Calam. Elevated plasma cholecystokinin at high altitude: metabolic implications for the anorexia of  acute mountain sickness? J. High Alt. Med. and Biol. 1: (1) 2000.

Bailey D.M., L.M. Castell, E.A. Newsholme and B. Davies. Continuous and intermittent exposure to the hypoxia of altitude; implications for glutamine metabolism and exercise performance. Brit. J. Sports Med. (in press)

Bailey D.M., B. Davies, A. Davies and M. Richards. Acute mountain sickness and dyspnoea; a common pathophysiology? Eur. J. Appl. Physiol. and Occupational Physiol. (in press)

Submitted

Bailey D.M., Davies B., Young I.S., HullinD.A. and Seddon P.S. Evidence for increased oxidative stress and muscle damage at terrestrial high altitude; a cause or consequence of acute mountain sickness? Submitted to the Journal of Applied Physiology.

Bailey D.M. Trekking at high altitude; a time not to be anorectic! New Scientist (to be published in 2000)

Abstracts

Bailey, D.M. B. Davies, M. Richards J.S. and Milledge.  Risk factors for acute mountain sickness at high altitude. J. Physiol. 523: P217P, 2000

Bailey, D.M. The metabolic stress of terrestrial high altitude Invited honorary lecture at the Congress for the Assessment of Stress Intensity and Stress Compatability in Large Groups, Austria, November 25th - 27th, 1999. First prize for International Young Investigators Award.

Bailey, D.M., Davies, B., Williams, S., Richards, M., Jordinson, M., and Calam, J. The physiochemical basis of appetite control at high altitude. Proceedings of the 40th Meeting of the Institute of Naval Medicine 5-6, 1999.  Oral presentation to the Institute of Naval Medicine, London, November 24th, 1999.

Bailey D.M., Davies B. and Newsholme E.A. Altitude hypoxia; The highs and lows. Accepted for a presentation to the House of Commons, Science, Engineering and Technology conference, April, 2000.

Bailey D.M., Davies, B., Williams, S., Richards, M., Jordinson, M., and Calam, J. Cachexia and acute mountain sickness at high altitude; a metabolic role of elevated plasma cholecysokinin. Accepted for an oral presentation at the ACSM 2000, Indiana, USA, May 31st - June 3rd, 2000 and to be published in Medicine and Science in Sports and Exercise.

Bailey D.M., Davies B., Hullin D.A., Seddon P.S. and Richards M. Muscle damage at high altitude; a role for systemic inflammation in the pathogenesis of acute mountain sickness? Oral presentation at the Second International Congress on Science, Austria, January 2000. First prize for best oral presentation.

Bailey, D.M. Davies, B. Richards, M. and Milledge, J.S. The pathogenesis of acute mountain sickness at high altitude Oral presentation at the 4th Annual Congress of the European College of Science, Rome, July, 1999.

Bailey DM, Davis B, Milledge JS, Castell LM, Newsholme EA, Ricahrds M, Jordinson M and Calam J (2000) A metabolic role for elevated plasma cholecystokinin in the anorexia and cachexia of AMS. High Altitude Medicine and Biology 1,1.

Abstract submitted

D.M. Bailey, B. Davies, J.S. Milledge, L.M. Castell, E.A. Newsholme, M. Richards, Jordinson M. and Calam J. A metabolic role for plasma cholecystokinin in the anorexia and cachexia of acute mountain sickness; a cause or consequence of elevated serotoninergic activity? Submitted for an oral presentation to the  hysiological Society, Imperial College, London. 

Book chapters

Bailey, D.M. and B. Davies. Physiological adaptation to environmental hypoxia; implications for exercise performance. In: Benefits and Hazards of Exercise (Ed: D. MacAuley) British  Medical Journal Books, London. p 277-304, 1999.

Bailey D.M., B. Davies, I.S. Young, D.A. Hullin and P.S. Seddon. Increased free radical mediated oxidative stress and skeletal muscle damage at high altitude; a cause or consequence  of acute mountain sickness? To be published in the 2nd Edition of Science and Skiing (ed Mueller, P). Publish date anticipated August, 2000.

Endothelin-1

Original Article

Cruden N.L., D.E. Newby, J.A. Ross, N.R. Johnston. and D.J. Webb. Effect of cold exposure, exercise and high altitude on plasma endothelin-1 and endothelial cell markers in man. Scott Med J. 44 (5): 143-6, 1999.*

Abstracts in Preparation

Woods D.R., A. Pollard, A. Everest , V. Vassiliou, S. Patel, Y. Jamshidi, D. Williams, S.E. Humphries and H.E. Montgomery.The ACE genotype and Oxygen Saturation at high altitude.

Woods D.R., A. Pollard, A. Everest , V. Vassiliou, S. Patel, Y. Jamshidi, D. Williams, S.E. Humphries and H.E. Montgomery. The ACE genotype and Heart Rate at high altitude.

  Abstracts

Bowen A.L., J.G. Hudson, P.  Navia, J. Rios-Dalenz, A.J. Pollard, D. Williams and D. Heath.  The Effect of Altitude on Blood Platelet Counts in Young Bolivian Airmen, In: Hypoxia, Women at Altitude Eds CS Houston & G Coates Burlington, Vermont USA. p305, 1997*

Hudson J.G., A.L. Bowen, P. Navia, J. Rios-Dalenz, A.J. Pollard, D. Williams and D. Heath. The effect of high altitude on platelet counts, thrombopoietin and erythropoietin levels in young Bolivian airmen visiting the Andes. Int. J. of Biometeorology Oct 25;43(2):85-90, 1999*

  Review Articles

Barry P.W. The effects of mountaineering on human physiology. Biol. Sci. Review. 8: 19-24, 1996*

Collier D., S. Currin and A.J. Pollard. Science on Mount Everest. The Alpine Journal. 163-174, 1996

Fry A. Eyes on Everest. Nursing Times. 91 (32): 38-39, 1995

Murdoch D.R. and A.J. Pollard. Mountain Sickness, Ten questions. J. of Travel Med. (in press)*

Nickol, A., and Collier D. Kangchenjunga 1998. In: Hypoxia: Into the Next Millennium, edited by R. C. Roach, P. D. Wagner and P. H. Hackett. New York: Plenum/Kluwer Academic Publishing. p. 323-333, 1999

Pollard A. When a child is at high risk. Hosp. Doctor. 7 September, 1995*

Pollard A.J. and D.R. Murdoch. Drugs for altitude sickness. Travel Med. International. 14: 211-15, 1996.*

Books

Pollard A, Murdoch DR. The High Altitude Medicine handbook. Radcliffe Medical press. Oxford. 1997.*

WARD, MILLEDGE AND WEST

  * denotes work carried out by Medical Expeditions members independent of Medical Expeditions

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